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1.

Inhibition of the renal apical sodium dependent bile acid transporter prevents cholemic nephropathy in mice with obstructive cholestasis.

Ghallab, Ahmed; González, Daniela; Strängberg, Ellen; Hofmann, Ute; Myllys, Maiju; Hassan, Reham; Hobloss, Zaynab; Brackhagen, Lisa; Begher-Tibbe, Brigitte; Duda, Julia C; Drenda, Carolin; Kappenberg, Franziska; Reinders, Joerg; Friebel, Adrian; Vucur, Mihael; Turajski, Monika; Seddek, Abdel-Latief; Abbas, Tahany; Abdelmageed, Noha; Morad, Samy A F; Morad, Walaa; Hamdy, Amira; Albrecht, Wiebke; Kittana, Naim; Assali, Mohyeddin; Vartak, Nachiket; van Thriel, Christoph; Sous, Ansam; Nell, Patrick; Villar-Fernandez, Maria; Cadenas, Cristina; Genc, Erhan; Marchan, Rosemarie; Luedde, Tom; Åkerblad, Peter; Mattsson, Jan; Marschall, Hanns-Ulrich; Hoehme, Stefan; Stirnimann, Guido; Schwab, Matthias; Boor, Peter; Amann, Kerstin; Schmitz, Jessica; Bräsen, Jan H; Rahnenführer, Jörg; Edlund, Karolina; Karpen, Saul J; Simbrunner, Benedikt; Reiberger, Thomas; Mandorfer, Mattias.

J Hepatol; 80(2): 268-281, 2024 Feb.

Artículo en Inglés | MEDLINE | ID: mdl-37939855

2.

Acetaminophen overdose causes a breach of the blood-bile barrier in mice but not in rats.

Hassan, Reham; Hobloss, Zaynab; Myllys, Maiju; González, Daniela; Begher-Tibbe, Brigitte; Reinders, Joerg; Friebel, Adrian; Hoehme, Stefan; Abdelmageed, Noha; Abbas, Aya A; Seddek, Abdel-Latief; Morad, Samy A F; Hengstler, Jan G; Ghallab, Ahmed.

Arch Toxicol; 98(5): 1533-1542, 2024 May.

Artículo en Inglés | MEDLINE | ID: mdl-38466352

3.

Integrated data from intravital imaging and HPLC-MS/MS analysis reveal large interspecies differences in AFB₁ metabolism in mice and rats.

Hassan, Reham; Gerdemann, Andrea; Cramer, Benedikt; Hobloss, Zaynab; Myllys, Maiju; González, Daniela; Albrecht, Wiebke; Veerkamp, Jannik; Friebel, Adrian; Hoehme, Stefan; Esselen, Melanie; Degen, Gisela H; Humpf, Hans-Ulrich; Hengstler, Jan G; Ghallab, Ahmed.

Arch Toxicol; 98(4): 1081-1093, 2024 Apr.

Artículo en Inglés | MEDLINE | ID: mdl-38436695

4.

Loss of bile salt export pump aggravates lipopolysaccharide-induced liver injury in mice due to impaired hepatic endotoxin clearance.

Remetic, Jelena; Ghallab, Ahmed; Hobloss, Zaynab; Brackhagen, Lisa; Hassan, Reham; Myllys, Maiju; Radun, Richard; Mlitz, Veronika; Zhu, Ci; Baumgartner, Maximilian; Schrottmaier, Waltraud C; Mussbacher, Marion; Timelthaler, Gerald; Scharnagl, Hubert; Stojakovic, Tatjana; Assinger, Alice; Fuchs, Claudia D; Hengstler, Jan G; Trauner, Michael.

Hepatology; 75(5): 1095-1109, 2022 05.

Artículo en Inglés | MEDLINE | ID: mdl-34927748

5.

Vinpocetine protects against chloroquine-induced cardiotoxicity by mitigating oxidative stress.

Abdelmageed, Noha; Twafik, Wael Ahmed-Anwar; Morad, Osama Abdel-Raouf; Haridy, Mohie; Hassan, Reham; Ahmed, Madeha; El-Zorba, Hesham Youssef; El-Banna, Hossny Awad; Seddek, Abdel-Latief; Ghallab, Ahmed; Morad, Samy Abdel-Raouf Fahim.

Arch Toxicol; 97(10): 2763-2770, 2023 10.

Artículo en Inglés | MEDLINE | ID: mdl-37401952

6.

Altering maternal calcium and phosphorus dietary intake induces persistent sex-specific changes in the dentition of the offspring.

Hassan, Mohamed G; Hassan, Reham; Hassan, Dina G; Abdelrahman, Hams H; Cox, Timothy C; Jheon, Andrew H.

Orthod Craniofac Res; 2023 Dec 07.

Artículo en Inglés | MEDLINE | ID: mdl-38059401

7.

Effect of continuous chelation on the dentinal tubule penetration of a calcium silicate-based root canal sealer: a confocal laser microscopy study.

Hassan, Reham; Roshdy, Nehal Nabil.

BMC Oral Health; 23(1): 377, 2023 06 09.

Artículo en Inglés | MEDLINE | ID: mdl-37296374

8.

Interruption of bile acid uptake by hepatocytes after acetaminophen overdose ameliorates hepatotoxicity.

Ghallab, Ahmed; Hassan, Reham; Hofmann, Ute; Friebel, Adrian; Hobloss, Zaynab; Brackhagen, Lisa; Begher-Tibbe, Brigitte; Myllys, Maiju; Reinders, Joerg; Overbeck, Nina; Sezgin, Selahaddin; Zühlke, Sebastian; Seddek, Abdel-Latif; Murad, Walaa; Brecklinghaus, Tim; Kappenberg, Franziska; Rahnenführer, Jörg; González, Daniela; Goldring, Christopher; Copple, Ian M; Marchan, Rosemarie; Longerich, Thomas; Vucur, Mihael; Luedde, Tom; Urban, Stephan; Canbay, Ali; Schreiter, Thomas; Trauner, Michael; Akakpo, Jephte Y; Olyaee, Mojtaba; Curry, Steven C; Sowa, Jan-Peter; Jaeschke, Hartmut; Hoehme, Stefan; Hengstler, Jan G.

J Hepatol; 77(1): 71-83, 2022 07.

Artículo en Inglés | MEDLINE | ID: mdl-35131407

9.

Inhibition of cytochrome P450 enhances the nephro- and hepatotoxicity of ochratoxin A.

Hassan, Reham; González, Daniela; Hobloss, Zaynab; Brackhagen, Lisa; Myllys, Maiju; Friebel, Adrian; Seddek, Abdel-Latif; Marchan, Rosemarie; Cramer, Benedikt; Humpf, Hans-Ulrich; Hoehme, Stefan; Degen, Gisela H; Hengstler, Jan G; Ghallab, Ahmed.

Arch Toxicol; 96(12): 3349-3361, 2022 12.

Artículo en Inglés | MEDLINE | ID: mdl-36227364

10.

Colchicine overdose impairs the capacity of Kupffer cells to clear foreign particles and endotoxins.

Hassan, Reham; Myllys, Maiju; Brackhagen, Lisa; Hobloss, Zaynab; González, Daniela; Seddek, Abdel-Latif; Friebel, Adrian; Hoehme, Stefan; Marchan, Rosemarie; Trauner, Michael; Hengstler, Jan G; Ghallab, Ahmed.

Arch Toxicol; 96(11): 3067-3076, 2022 11.

Artículo en Inglés | MEDLINE | ID: mdl-36102954

11.

Hypoalbuminemia affects the spatio-temporal tissue distribution of ochratoxin A in liver and kidneys: consequences for organ toxicity.

Hassan, Reham; Friebel, Adrian; Brackhagen, Lisa; Hobloss, Zaynab; Myllys, Maiju; González, Daniela; Albrecht, Wiebke; Mohammed, Elsayed S I; Seddek, Abdel-Latif; Marchan, Rosemarie; Cadenas, Cristina; Cramer, Benedikt; Humpf, Hans-Ulrich; Hartl, Lukas; Simbrunner, Benedikt; Reiberger, Thomas; Trauner, Michael; Hoehme, Stefan; Degen, Gisela H; Hengstler, Jan G; Ghallab, Ahmed.

Arch Toxicol; 96(11): 2967-2981, 2022 11.

Artículo en Inglés | MEDLINE | ID: mdl-35962801

12.

Regenerative endodontic procedures for the treatment of necrotic mature teeth: A preliminary randomized clinical trial.

Youssef, Ahmed; Ali, Magdy; ElBolok, Amr; Hassan, Reham.

Int Endod J; 55(4): 334-346, 2022 Apr.

Artículo en Inglés | MEDLINE | ID: mdl-35030270

13.

Subcellular spatio-temporal intravital kinetics of aflatoxin B₁ and ochratoxin A in liver and kidney.

Ghallab, Ahmed; Hassan, Reham; Myllys, Maiju; Albrecht, Wiebke; Friebel, Adrian; Hoehme, Stefan; Hofmann, Ute; Seddek, Abdel-Latif; Braeuning, Albert; Kuepfer, Lars; Cramer, Benedikt; Humpf, Hans-Ulrich; Boor, Peter; Degen, Gisela H; Hengstler, Jan G.

Arch Toxicol; 95(6): 2163-2177, 2021 06.

Artículo en Inglés | MEDLINE | ID: mdl-34003344

14.

Bile Microinfarcts in Cholestasis Are Initiated by Rupture of the Apical Hepatocyte Membrane and Cause Shunting of Bile to Sinusoidal Blood.

Ghallab, Ahmed; Hofmann, Ute; Sezgin, Selahaddin; Vartak, Nachiket; Hassan, Reham; Zaza, Ayham; Godoy, Patricio; Schneider, Kai Markus; Guenther, Georgia; Ahmed, Yasser A; Abbas, Aya A; Keitel, Verena; Kuepfer, Lars; Dooley, Steven; Lammert, Frank; Trautwein, Christian; Spiteller, Michael; Drasdo, Dirk; Hofmann, Alan F; Jansen, Peter L M; Hengstler, Jan G; Reif, Raymond.

Hepatology; 69(2): 666-683, 2019 02.

Artículo en Inglés | MEDLINE | ID: mdl-30102412

15.

Spatio-temporal visualization of the distribution of acetaminophen as well as its metabolites and adducts in mouse livers by MALDI MSI.

Sezgin, Selahaddin; Hassan, Reham; Zühlke, Sebastian; Kuepfer, Lars; Hengstler, Jan G; Spiteller, Michael; Ghallab, Ahmed.

Arch Toxicol; 92(9): 2963-2977, 2018 09.

Artículo en Inglés | MEDLINE | ID: mdl-30039229

16.

Adverse outcome pathways: opportunities, limitations and open questions.

Leist, Marcel; Ghallab, Ahmed; Graepel, Rabea; Marchan, Rosemarie; Hassan, Reham; Bennekou, Susanne Hougaard; Limonciel, Alice; Vinken, Mathieu; Schildknecht, Stefan; Waldmann, Tanja; Danen, Erik; van Ravenzwaay, Ben; Kamp, Hennicke; Gardner, Iain; Godoy, Patricio; Bois, Frederic Y; Braeuning, Albert; Reif, Raymond; Oesch, Franz; Drasdo, Dirk; Höhme, Stefan; Schwarz, Michael; Hartung, Thomas; Braunbeck, Thomas; Beltman, Joost; Vrieling, Harry; Sanz, Ferran; Forsby, Anna; Gadaleta, Domenico; Fisher, Ciarán; Kelm, Jens; Fluri, David; Ecker, Gerhard; Zdrazil, Barbara; Terron, Andrea; Jennings, Paul; van der Burg, Bart; Dooley, Steven; Meijer, Annemarie H; Willighagen, Egon; Martens, Marvin; Evelo, Chris; Mombelli, Enrico; Taboureau, Olivier; Mantovani, Alberto; Hardy, Barry; Koch, Bjorn; Escher, Sylvia; van Thriel, Christoph; Cadenas, Cristina.

Arch Toxicol; 91(11): 3477-3505, 2017 Nov.

Artículo en Inglés | MEDLINE | ID: mdl-29051992

17.

Modification of acetaminophen-induced hepatotoxicity by autophagy.

Hassan, Reham.

Arch Toxicol; 94(7): 2545-2546, 2020 07.

Artículo en Inglés | MEDLINE | ID: mdl-32588085

18.

Modelling of liver regeneration after hepatectomy.

Seddek, Abdel-Latif; Hassan, Reham.

Arch Toxicol; 94(10): 3605-3606, 2020 10.

Artículo en Inglés | MEDLINE | ID: mdl-32865615

19.

Acetaminophen induces programmed necrosis.

Hassan, Reham.

Arch Toxicol; 93(12): 3641-3642, 2019 12.

Artículo en Inglés | MEDLINE | ID: mdl-31728590

20.

Highlight report: predicting hepatotoxic oral doses of chemicals by in vitro testing and in silico modeling.

Hassan, Reham.

Arch Toxicol; 93(9): 2707-2708, 2019 09.

Artículo en Inglés | MEDLINE | ID: mdl-31346659

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Inhibition of the renal apical sodium dependent bile acid transporter prevents cholemic nephropathy in mice with obstructive cholestasis.

Acetaminophen overdose causes a breach of the blood-bile barrier in mice but not in rats.

Integrated data from intravital imaging and HPLC-MS/MS analysis reveal large interspecies differences in AFB₁ metabolism in mice and rats.

Loss of bile salt export pump aggravates lipopolysaccharide-induced liver injury in mice due to impaired hepatic endotoxin clearance.

Vinpocetine protects against chloroquine-induced cardiotoxicity by mitigating oxidative stress.

Altering maternal calcium and phosphorus dietary intake induces persistent sex-specific changes in the dentition of the offspring.

Effect of continuous chelation on the dentinal tubule penetration of a calcium silicate-based root canal sealer: a confocal laser microscopy study.

Interruption of bile acid uptake by hepatocytes after acetaminophen overdose ameliorates hepatotoxicity.

Inhibition of cytochrome P450 enhances the nephro- and hepatotoxicity of ochratoxin A.

Colchicine overdose impairs the capacity of Kupffer cells to clear foreign particles and endotoxins.

Hypoalbuminemia affects the spatio-temporal tissue distribution of ochratoxin A in liver and kidneys: consequences for organ toxicity.

Regenerative endodontic procedures for the treatment of necrotic mature teeth: A preliminary randomized clinical trial.

Subcellular spatio-temporal intravital kinetics of aflatoxin B₁ and ochratoxin A in liver and kidney.

Bile Microinfarcts in Cholestasis Are Initiated by Rupture of the Apical Hepatocyte Membrane and Cause Shunting of Bile to Sinusoidal Blood.

Spatio-temporal visualization of the distribution of acetaminophen as well as its metabolites and adducts in mouse livers by MALDI MSI.

Adverse outcome pathways: opportunities, limitations and open questions.

Modification of acetaminophen-induced hepatotoxicity by autophagy.

Modelling of liver regeneration after hepatectomy.

Acetaminophen induces programmed necrosis.

Highlight report: predicting hepatotoxic oral doses of chemicals by in vitro testing and in silico modeling.